Here it is the secret of elephants rarely infected with cancer. Can it be applied to humans?

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Here it is the secret of elephants rarely infected with cancer - Currently, around 17% of deaths worldwide are caused by cancer. While the number of elephants that die from cancer is only 5% when the average age of their lives is the same as humans, which is around 70 years.

Out of curiosity, a team led by a human geneticist, Vincent Lynch, who teaches at the University of Chicago and researchers from the University of Utah then examined this.

They suspect this may be related to the presence of the p53 gene which functions to suppress tumors in elephants. The specialty of this gene is to recognize damaged DNA and push it into programmed cell death, also called autophagy.

So the diseased cells will be damaged and digested by the body's own immune system so that it cannot develop into tumor cells.

This gene actually also exists in humans and in almost all mammals, at least one copy of the gene.

Gen zombie
To their surprise, the elephants did not only have one but 20 copies of the p53 gene in their genetic makeup. As a result, these cells react much more sensitive to any damage to the genome and start cell death earlier.

However, through this study, the researchers also found another breakthrough. "Genes duplicate themselves all the time," Lynch said. "Sometimes they also make mistakes, producing a version of a nonfunctional gene known as pseudogenes."

While continuing to examine the p53 gene, the researchers discovered a pseudogene called leukemia 6 inhibiting factors (LIF6). Remarkably, the pseudogene elephant can suddenly function again. In other words, this gene rises from the dead.

Genes are like zombies, which then destroy the energy supply of diseased cells.

LIF6 works by punching holes in the mitochondria that function as power plants in cells and causing the diseased cells to die. "Like a zombie. This dead gene revives. It is revived by damaged DNA cells and then kills those cells, quickly," Lynch explained.

"This is beneficial for elephants, because these cells act in response to genetic errors, and also mistakes made when DNA is being repaired. Getting rid of those cells can prevent next cancer."

The researchers published their research in the journal Cell Reports on August 14, 2018.

Can it be applied to humans?
The LIF6 gene is thought to have been active in elephants for millions of years. This gene also seems to have existed in the bodies of modern elephant ancestors today, the Hyrax that lived around 25 to 30 million years ago.

The height of Hyrax at that time was almost no greater than that of a guinea pig. The mechanism of cancer cell proliferation may be also responsible for the size of the elephant.

Large animals have more cells and cell division systems than smaller animals. For this reason, the researchers assume that they also need a very effective mechanism to suppress or remove tumor cells.

Lynch and his colleagues now want to try using an elephant strategy in the treatment of cancer of the human body.

"Maybe we can find a way to develop drugs that can mimic the behavior of LIF6 in elephants or make cancer cells to revive copies of their zombie cells," he said.

7 Ways to Eliminate Uban Naturally

Gray or gray hair or hair that turns grayish to white is often associated with symptoms of aging. But in fact, many people already have gray hair at a relatively young age. This often makes a person less confident and want to find ways to get rid of gray hair quickly.

Basically, the appearance of white hair is indeed influenced by several factors. Besides being caused by aging, gray hair can also arise due to lack of vitamin hair, stress, genetic factors, use of chemicals, and lack of folic acid in the body.

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List of Ways to Get Rid of Uban Naturally & Quickly

Many people choose to dye their hair with hair dye as a way to overcome gray hair. But if you want to use a safer method, here are 7 ways to get rid of gray hair naturally that you can use!

1. Coconut and Lemon Oil

The first way to deal with gray hair is to use a mixture of coconut oil and lemon. Coconut oil contains lots of vitamin E, vitamin K, and also iron which can help to stimulate cell regeneration in the hair shaft. The content of vitamin C in lemons is no less important for hair health. Mixing coconut oil with lemon will also help provide a fresher aroma than if you only use oil.

How to use it is by mixing the juice of one lemon with 5 tablespoons of coconut oil. Mix well in a container, then apply to all hair while gently massaging the scalp. Let stand for 10 to 30 minutes so that the oil seeps in the hair, then rinse with clean water.

2. Candlenut Oil

Hazelnut oil has been known to have properties to make hair thicker and blacker. The content of vitamins and fatty acids in hazelnut oil makes it often used as an ingredient for shampoo products and conditioner. It turns out that hazelnut oil can also be one way to get rid of gray hair.

You can use candlenut oil products on the market or make your own hazelnut oil at home. How to make hazelnut oil is by burning the hazelnut until it is scorched, then mashing and squeezing the oil. Apply hazelnut oil as a hair mask before you go to sleep and rinse in the morning.

3. Potato Skin

Did you know that potato skin can be used as an alternative to overcome gray hair? Starch in potatoes is useful as a natural hair dye. The trick is to mix one glass of clean potato skin with two glasses of water, then boil for about 25 minutes. After that, strain the potatoes and let the water cool.

If you don't like the aroma of the liquid, you can mix it with a little essential oil. Apply the liquid to the hair after you are in harmony. You can use your hands directly or use a brush like applying hair dye. Do it every few weeks to get the hair color you want.

4. Guava Leaf

Guava leaves are known to have many health benefits such as overcoming diarrhea and increasing platelets. On the other hand, guava leaves also have many benefits for hair care. The content of vitamin C and high antioxidants in guava leaves can strengthen hair and maintain hair pigmentation.

How to get rid of gray hair with guava leaves is by pounding some guava leaves until smooth and mix with a little water. Then apply the mixture to all hair and scalp while massaging it gently. Leave the hair for half an hour, then rinse with clean water. Do it at least twice a week for maximum results.

5. Bombay onions

The high content of the enzyme catalase in onions can remove hydrogen peroxide which is one of the causes of gray hair growth. The content of vitamins and other compounds in onions are also very good for avoiding hair from hair loss and dandruff problems. The way to overcome gray hair with onions is by grating the onions and then filtering them. Apply onion juice to all hair, then wrap coconut using a towel or shower cap. Let stand up to 30 minutes, then rinse with clean water and shampoo.

6. How to get rid of gray hair with Shoes Flower

Another natural ingredient that is believed to be effective in dealing with gray hair is hibiscus or hibiscus flowers. The content of polyphenols and also saponins in hibiscus can help to overcome gray hair. One way to get rid of gray hair with hibiscus is by mixing hibiscus oil with olive oil, coconut oil, or hazelnut oil.

Heat one of these oils, then mixes with several pieces of shoe flower petals. After the oil cools down, apply the oil to the entire head and let it sit for up to 30 minutes. Then rinse your hair with shampoo and clean water.

7. Consumption of Foods with High Folic Acid and Vitamin B12

In addition to using a way to deal with gray hair from the outside, you can also accompany it with care from the inside. Lack of folic acid and vitamin B12 can also be a factor in the appearance of gray hair. Consumption of more food with folic acid and vitamin B12 will help to maintain hair pigmentation.

You can get folic acid from vegetables such as greens, broccoli, spinach, and cabbage as well as fruits such as avocados, beets, papaya, bananas. While a high intake of vitamin B12 you can get from the consumption of animal meat, fish, shellfish, and cereals.

Well, that's 7 ways to get rid of gray hair naturally you can do. Start applying and get your black hair back like it used to be.

Dietary Supplements Definition ?

Karyadi (1997), dietary supplements definition as foods that contain nutrients and non-nutrients, can be in the form of capsules, soft capsules, powdered or liquid tablets which function as a supplement to the lack of nutrients needed to keep the vitality of the body to be excellent. According to Yulliarti (2008), dietary supplements are defined as substances or additional food ingredients consumed.

Substances or food ingredients can be vitamins, minerals, herbs or medicinal plants, amino acids or parts of substances or food ingredients. This food supplement is a companion or addition to a certain diet, nutrition, or body condition programs, and is not a substitute for food.

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BPOM (2004) defines dietary supplements as products intended to supplement the nutritional needs of food, containing one or more of the ingredients in the form of vitamins, minerals, amino acids or other ingredients (derived from plants or not plants) that have nutritional value and deep physiological effects concentrated amount. Dietary supplements can be solid products including tablets, lozenges, chewable tablets, powders, capsules or liquid products in the form of drops, syrup, solution.

Management of Dietary Supplements.

Initially the use of supplements is still limited to returning metabolic functions where the entire process is controlled by enzymes as catalysts of the body's chemical reactions that make cells work optimally.


But next, the use of supplements is no longer limited to vitamins and minerals now the limits of nutritional supplements are widening to include nutrients and healers found in herbs and other natural medicinal ingredients. (Vitahealth, 2004) .

People Who Need Dietary Supplements

1. Mothers are pregnant and mothers are breastfeeding because they need more nutrition than ordinary people, especially vitamins and minerals. Doctors generally recommend folic acid and iron to fulfill their physiology.
2. Individuals with certain diseases or certain disorders need nutritional needs that are also more than AKG (Nutritional Adequacy Rate) which is recommended especially certain vitamins. For example, those who are at risk for chronic heart disease (CHD) and stroke are advised to use supplements that contain vitamin B and folic acid. Also in those who have impaired absorption of fat, will reduce the ability to absorb fat-soluble vitamins
3. Individuals who need to take medication to prevent some diseases can lack certain vitamins. For example, taking antibiotics can kill intestinal bacteria and reduce the production of vitamin K. In such conditions, these vitamin needs must be purchased with a prescription from a doctor. Smoking and drinking alcohol also increases the need for vitamins, especially vitamin B
4. Elderly people who are generally not fulfilled their nutritional needs in accordance with the RDA, especially lack of vitamin B6 and vitamin D as well as vitamin B12 due to limitations in the teeth, tongue which decreases the ability to taste it, the type of food that must be softer than young people.
5. People who don't eat meat (vegan) need to take vitamin B12 supplements
6. Individuals who need to be under 1200 Calories to lose weight (especially athletes), require additional supplements to fulfill their AKG
7. Individuals who are physically very active and not enough nutritional intake compared to their needs need supplements

Dangers of Dietary Supplements

Excess vitamin C may be excreted in the urine. But other types of vitamins (A, D, E, and K) generally settle in the body and are worried that they can interfere with organ function, especially the liver and kidneys.

Proteins that are usually found in supplements when consumed by certain people can cause allergic effects.

Excessive iron consumption is not good for sufferers of vaginal disorders such as thalassemia.

Consumption of vitamin K supplements in people who are taking certain medications sometimes worsens the situation.

Factors Associated with Consumption of Dietary supplements

• Gender

One of the demographic characteristics associated with high use of supplements (especially multitudinary supplements) is women (Greger, 2001). Lyle at al (1998) states that, compared to men, women consume multi-nutrient supplements more often and supplement vitamin C and E. These results remain the same when adjusted for age.

Utami (1998) in Anggondowati (2002), states that the results of the Subar and Block studies show that the highest use of supplements is in women, as much as 26.8% according to the NCHS survey results (Frankle et al, 1993). combination of vitamins and multivitamins.

• Disease history

The desire to achieve better physical status and self-treatment of disease is the reason for consuming dietary supplements (Frank et.al. 1993). According to White et al. (2004) the condition of the body that is not good, or moderate in a sick condition or having complaints about health encourages them to use supplements.

According to Bender et al. (1992) suggested that supplement use is related to individuals who have one or more health problems.

Dietary supplements are foods that contain nutrients and non-nutrients, can be in the form of capsules, soft capsules, tablets, powders, or liquids that function as a supplement to the lack of nutrients needed to keep the vitality of the body to be excellent. As a compliment, dietary supplements are not interpreted as substitutes (substitutions) for our daily food (Ida, 2009).

Dietary supplements are classified as nutraceuticals, while drugs are in the pharmaceutical group. Unlike drugs that have to be clinically tested for effectiveness following a series of procedures, the dietary supplement does not need to be proven through clinical trials. Until now, any type of nutraceutical can be sold freely, but it should not be claimed to have the properties to treat diseases, such as drugs (Wuri, 2008).

The word nutraceutical is a combination of the words nutrition and pharmaceutical, which means the product has a beneficial effect on human health. Nutraceuticals are often referred to as functional foods. These food products can improve health and also prevent disease.

Follow 5 Dietary Weight Loss Tips Naturally

Dietary Weight Loss - Have you ever tried to lose weight but instead felt not fit? Maybe the diet you are doing is not right so that your body is overwhelmed. Try a natural diet!

Yes, having a natural diet is the safest solution for losing weight. The method that is relatively simple and does not suppress the body excessively makes it safer to go to a body shape dream.

Are you intending to start immediately? Check out the first five natural dietary weight loss tips below!

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1. Don't Let the Body Starve

Diet with hunger but instead revenge overeating? Believe me, this case has happened a lot and far from success.

Leaving the stomach to a very hungry state will only make it harder for you to hold your appetite when you have food. As a result, you will forget about natural diets by consuming healthy foods and instead eat whatever is in plain sight.

To overcome this, always provide healthy supplies in your bag. Small but highly nutritious foods such as boiled eggs, yogurt or banana greek can meet your body's needs immediately without leaving excessive calories.

2. Make sure your body is always hydrated by water

Are you among those who prefer to consume soft drinks while eating lunch in the cafeteria? If so, maybe you should change the habit now.

It's no secret that water is the most essential thing for the body. Indeed, the water needs for each person are different. But, by drinking more water can support a natural diet weight-loss.

Try to drink water for at least 2 liters a day by getting used to carrying a drinking bottle with you. That way, you will feel full longer later if the water needs in the body are fulfilled.

3. Give Enough Sleep to Your Body

Who says that activities that can lose weight just exercise? Don't get me wrong, sleep is also one part of a natural diet!

Our bodies do need exercise but don't forget to restore energy with enough sleep. Many studies that mention the habit of sleep deprivation can cause a lot of harm to our body, the risk of diabetes for example. This certainly can be a metabolic inhibitor to the maximum.

In order for your body to get maximum regeneration, improve your lifestyle with adequate sleep, for example, 6 to 8 hours a day. That way, your metabolism will be improved and ready to welcome your ideal weight.

4. Reduce Salt Consumption

If you like savory food, from now on you have to reduce it.

Reducing salt consumption is one of the best known natural diet methods. Why is that? Excessive sodium consumption can make it difficult for our bodies to process fat metabolism. Of course, you don't want your stomach and cheeks to continue to bulge, right?

Try to get used to consuming vegetables, chicken, or eggs without added salt. To keep getting the savory taste in the cuisine, you can use genuine sea salt that contains less sodium or add cottage cheese to an omelet. By reducing salt consumption, your blood pressure can also be controlled.

5. Make Apple Snacks Mandatory

“An apple a day keeps the doctor away”

It is so, it is no secret that apples contribute a lot about natural diets. An apple has less than 200 calories with high protein and fiber content so it can help your body to hold your appetite. In addition, apples are also able to regulate blood sugar levels to remain stable and ready to make you stay strong. Consume apples at least twice a day, don't forget to take part in eating the skin because there is a lot of fiber there.

Easy enough, right?

Even though there are many natural diet tips, don't forget regular exercise so that your body remains excellent. Also, prepare for your health protection. 

4 Brain Supplements That Can Improve Your Memory

Brain Supplements That Can Improve Your Memory - Proper intake of nutrients does indeed play an important role in brain health. Unfortunately, not everyone is able to meet their nutritional needs only from the food they consume daily. Some people may need additional nutritional intake from supplements. If you are one of them, here are some supplements for the brain that you can consume every day. However, make sure you consult a doctor first before taking the supplements below.

Various choices of brain supplements that you can consume

1. Vitamin B12

Scientists have long examined the relationship between low levels of vitamin B12 (cobalamin) and memory. Vitamin B12 plays a role in the formation of myelin, a fatty substance that lines and protects nerve fibers in the brain and spinal cord.

According to an expert at the Mayo Clinic, adequate B12 intake in your diet can help protect them

brain from nerve damage, improve memory and reduce the risk of decreased mental function.

2. Vitamin E

There is some evidence that vitamin E can be beneficial for the mind and memory in the elderly. Although vitamin E does not seem to reduce the risk of Alzheimer's disease, this vitamin is believed to be able to slow the progression of this disease.

However, you must be careful when taking supplements for this brain. Because, consuming more than 1,000 IU of vitamin E per day is very risky for people with heart disease, especially for those who are on blood thinning treatment. High doses of vitamin E also increase the risk of prostate cancer.

That is why make sure you always consult a doctor before deciding to take this supplement.


3. Omega-3 fatty acids


Omega-3 fatty acids are one of the important nutrients for brain development. Studies show that a higher intake of omega-3 fatty acids from foods such as fish and vegetable oils can help ward off Alzheimer's.

Another study also found that people who took fish oil supplements were safer from the weakening (atrophy) of the brain than those who did not consume fish oil.

4. Acetyl-L-carnitine

Several studies have shown that the synthesis of the amino acid carnitine can help Alzheimer's patients with memory disorders. This supplement can provide greater benefits for people who have Alzheimer's at a young age, or whose Alzheimer's progression rate is very fast.

For some people, supplements are indeed able to meet the intake of nutrients and vitamins that they do not get from food consumed daily. However, make sure you always consult a doctor first before deciding to take supplements. This is so that you get a dose of daily intake that is safe and according to your needs.

Another best way to improve your memory

Actually, there are several other ways that are important keys to improve your brain's memory and cognitive functions, namely:

1. Pay attention to nutritional intake

Food plays an important role in maintaining health, including your brain. Even what you consume will also affect your mood, brain energy, memory, and your body's ability to deal with stress.

Meeting the needs of glucose and complex carbohydrates will provide enough energy for the brain to perform its functions. Some good foods for the brain include fish, dark green leafy vegetables, fresh fruit, whole wheat, and so on.

2. Regular exercise

Regular exercise and physical activity can affect a person's cognitive function. With physical activity, the brain will work optimally to produce proteins brain-derived neurotrophic factor (BDNF), which helps increase blood flow to the brain and prevent damage to brain cells.

3. Sleep enough

Sleep is the best way to rest your brain. Because lack of sleep can reduce brain function to think and process information. Meeting the need for sleep for around 7 hours every night will provide more energy for the brain so that the brain can concentrate more easily.

4. Manage stress

Prolonged stress will increase the hormone cortisol level. As a result, it can reduce brain function, make you experience mood disorders, and experience learning difficulties. Well, yoga and meditation will help you to manage stress. That way the hormone cortisol will not increase continuously.